Department of Chemistry, Brown University, Providence, RI, 02912, USA. Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (NIPS) and Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, 444-8787, Japan. Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA. Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan. takaike@med.tohoku.ac.jp. Department of Chemistry, Brown University, Providence, RI, 02912, USA. ming_xian@brown.edu.